Hemus Hotel is directly above European Union Metro Station, with a station entrance immediately next to the hotel entrance. Most nearby bus and trolleybus stops bear the Hemus Hotel name, while central Sofia, Vitosha Boulevard and major landmarks are all within easy reach.

Sofia Central Railway Station is 3.7 km from the hotel. Sofia Airport is easily reached by metro from European Union Station, with one change at Serdika; Terminals 1 and 2 are 6.7 km and 7.5 km away respectively.

The National Palace of Culture is 800 meters from the hotel, while the pedestrian section of Vitosha Boulevard—with its shops, restaurants and cafés—is  1 km away.

For sport and leisure, Spartak Swimming Complex is 850 meters from the hotel, while Vasil Levski National Stadium and Borisova Gradina Park are 1.5 km and 1.6 km away. Alexander Nevsky Cathedral is 2.2 km away.

All distances are approximate straight-line measurements from Hemus Hotel.